Inhibitor Apoptosis Library

inhibitor Apoptosis Library Chemical Structure: MIK665 CAS No.: 1799631-75-6 聽 MIK665(MIK 665, S 64315, S64315) Catalog No.: URK-V595聽聽Only Used For Lab. MIK665 (S-64315, MIK-665) is a novel potent, selective Mcl-1 inhibitor (IC50=1.8 nM) with potential pro-apoptotic and antineoplastic activities. 聽 Biological Activity MIK665 (S-64315, MIK-665) is a novel potent, selective Mcl-1 inhibitor (IC50=1.8 nM) with potential pro-apoptotic and antineoplastic activities. MIK665 (S-64315) binds to and inhibits the activity of Mcl-1, which promotes apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival. 聽 Physicochemical Properties M.Wt875.413 FormulaC47H44ClFN6O6S CAS No.1799631-75-6 StorageSolide Powder -20 掳C 3years; 4掳C 2yearsIn Solvent -80掳C 6 Months -20掳C 1 Months Solubility10 mM in DMSO Chemical Name(R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid 聽 References 1. Cassier PA, et al. Br J Cancer. 2017 Oct 10;117(8):1089-1098. URK-V595_COA URK-V595_SDS URK-V595_TDS 聽 Note: All products of Ureiko are only used for scientific research or drug certificate declaration, and we do not provide products and services for any personal use 聽inhibitor Apoptosis Library website:http://www.ureiko-chem.com/inhibitors-agonists/apoptosis-library/